Two simple and sensitive visible spectrophotometric methods (A-B) for the determination of Cefprozil (CEF) in bulk sample and pharmaceutical formulations are described. Methods A and B are based on the formation of ion-association complex involving carboxylic acid group of CEF and the basic dyes, safranin-O (SFN-O, method A), methylene blue (MB, method B). The results obtained in the two methods are reproducible and are statistically validated and found to be suitable for the assay of Cefprozil in bulk and pharmaceutical formulations.
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